It is fully located in Caceres and it extends over an area of some 115,000 hectares grouping 14 municipalities. It was declared in 2003 and is managed by the Autonomous Community of Extremadura. He was promoted because of its Mediterranean landscape, the harmony between vegetation, natural values, especially thanks to the progressive and balanced human intervention in their dehesas.

It included within the Monfragüe National Park, the LIC Monfragüe, ZEPA Monfragüe  and  environment meadows. The main natural value of Monfragüe is the ornithological wealth, with some of the largest colonies of black vulture, black stork, eagle owl or Spanish imperial eagle of Europe and even the world.

The flora also figures prominently, with a number close to 1,300 different taxa. Its location, in a transition zone between the south and north, favors the existence of endemism and minority formations such as flueggea tinctorea, almezales, etc,

The local municipalities that are included in the Reserve also have a great artistic heritage with churches in Gothic-Renaissance style. Four of them are declared Cultural Relevance. In addition, three bridges are remarkable historical relevance: the Bridge Cardinal (1450) and the Bridge Albalat (XVI) both over the Tagus River and the bridge over the River Almonte (XV and XVI) in Jaraicejo.

As conservation activities highlight the elimination of 1,255 hectares of plantations of eucalyptus and the recovery of native vegetation that was in it by the time of planting four decades ago.